Troubleshooting LC-MS
This learning path on troubleshooting LC-MS covers common issues like low sensitivity, ion suppression, peak tailing, and mass accuracy errors. It includes diagnosing problems with ionization, mobile phase composition, contamination, and vacuum system performance. Practical strategies focus on tuning, maintenance, and optimizing method parameters for reliable, high-sensitivity analysis.
1 Webcast 6 Quick Guides
7 Items
My LC-MS Isn’t Behaving! Where Do I Start?
A quick guide about where to start when your LC-MS stops working.
Troubleshooting LC-MS
LC-MS is a complex technique which makes troubleshooting that little bit more challenging. We will take you through a step-by-step approach which can be used to determine if the problem is related to the method/sample or if it is an instrument fault - and then how to further narrow the source of the issue to particular LC or MS components.
10(ish) Ways to Prevent LC-MS Contamination
Top tips to keep your LC-MS up and running longer and producing the best possible data.
Avoiding LC-MS Signal Suppression
Some practical insights into optimizing LC-MS eluents and parameters to avoid signal suppression.
Controlling Na and K Adducts in LC-MS
The sources of adduct ions are prolific, but an understanding of these sources can help to eliminate or reduce the occurrence of adduct ions. Find out more in this guide to controlling Na and K adducts in LC-MS.
