Controlling Na and K Adducts in LC-MS

Adduct ions are prevalent in LC-MS analyses and can come from any number of sources. An adduct ion is any ion formed by adduction of an ionic species to a molecule, and can be present under all modes of ionization (e.g. ESI, APCI etc.) and under different ionization polarities (positive or negative ionization). The sources of adduct ions are prolific, but an understanding of these sources can help to eliminate or reduce the occurrence of adduct ions. Find out more in this guide to controlling Na and K adducts in LC-MS.