Troubleshooting
Improve your LC-MS troubleshooting skills with expert-led training designed to help you identify and resolve common issues. Learn to diagnose ionization problems, signal loss, low sensitivity, retention time shifts, peak broadening, and contamination for accurate, reproducible results. Understand how solvent selection, buffers, flow rates, and ion source tuning impact system performance. Ideal for professionals in pharmaceuticals, environmental testing, food safety, forensics, and clinical research, this course includes video tutorials, real-world case studies, and troubleshooting checklists. Start learning today to keep your LC-MS system running at peak performance!
My LC-MS Isn’t Behaving! Where Do I Start?
A quick guide about where to start when your LC-MS stops working.
Avoiding LC-MS Signal Suppression
Some practical insights into optimizing LC-MS eluents and parameters to avoid signal suppression.
10(ish) Ways to Prevent LC-MS Contamination
Top tips to keep your LC-MS up and running longer and producing the best possible data.
Controlling Na and K Adducts in LC-MS
The sources of adduct ions are prolific, but an understanding of these sources can help to eliminate or reduce the occurrence of adduct ions. Find out more in this guide to controlling Na and K adducts in LC-MS.
10 Ways to Break Your LC-MS
Avoid these 10 common errors to ensure reliable LC-MS operation.
Troubleshooting LC-MS
LC-MS is a complex technique which makes troubleshooting that little bit more challenging. We will take you through a step-by-step approach which can be used to determine if the problem is related to the method/sample or if it is an instrument fault - and then how to further narrow the source of the issue to particular LC or MS components.
ESI Signal Suppression
This video guide will allow you to understand what causes signal suppression in ESI and how it can be avoided.