Quadrupole Analyzers and MS/MS Analysis

This webcast presents a definitive guide to the theory, instrumentation and application of quadrupole analysers and MS/MS analysis. The session will initially consider the need for mass analyzers before concentrating on the quadrupole, which has become a mainstay for the majority of analytical laboratories. The impact the quadrupole design, geometry and applied voltages have on ion stability will be investigated. Special attention will be reserved for the electrostatic fields created within the quadrupole and the resulting equations of motion. Quadrupole resolution, sensitivity and mass accuracy will also be considered. We will then continue to review the additional benefits and design changes required in order to operate quadrupoles in tandem (MS/MS). Typical MS/MS experiments will then be reviewed individually and their specific operation and benefits presented and explained.

Topics include:

• Quadrupole history, design, orientation, and geometry
• Applied voltages and ion trajectories
• Equations of motion
• Mathieu stability diagrams
• Mass range, accuracy, resolution, and sensitivity
• RF only ion bridges
• Tandem MS/MS design and benefits
• Common MS/MS experiments