HPLC Method Troubleshooting

Troubleshooting is a task that all chromatographers must undertake routinely. Some problems seem to be resolved quickly while others can be much more onerous. Having a good troubleshooting strategy which can be applied to all problems is essential, therefore, using examples of real-life chromatographic problems we will provide you with the knowledge you need to become the expert troubleshooter in your lab.

Topics include:

• Troubleshooting strategies
• Peak splitting
• Retention time changes
• Baseline issues
• Extra peaks