Technique

GC-MS Ionization

An introduction to the ionization processes which occur in GC-MS. Ionization is the process whereby electrons are either removed or added to atoms or molecules to produce ions.

GC Considerations

This module explores the main GC considerations when using MS detectors. The choice of column phase and dimensions are considered, as well as the effects of carrier gas flows on the MS vacuum system.

Fundamentals of GC-MS Ionization Techniques

This quick guide gives a concise overview of GC-MS ionization technique.

GC-MS/MS Analysis – What You Need to Know!

In this webcast, we explore the theory, technology, and applications of GC-MS/MS. We will discuss the key features of GC-MS/MS instrumentation alongside an overview of the key instrument operating principles and theories. Various means of deriving MS/MS spectral information will be discussed with reference to the analyzers which make these experiments possible.

What GC-MS Operators Need to Know

This informative webcast discusses special GC considerations, how analyte ionization works, and the principles of mass analysis using quadrupole devices. We will show you how to interpret an MS tune report, the power of various MS operating modes, and how to process and understand the data you generate. This essential information will allow you to better implement this technique successfully in your laboratory.

GC-MS Ionization Processes

This webcast discusses the two main forms of ionization, electron ionization (EI) and chemical ionization (CI) in GC-MS. The molecular reactions which occur within the ion source to produce ions will be examined along with which form of ionization should be used for particular analytes. Finally, our speakers will impart some of their expert knowledge regarding optimization of the GC-MS process and some general interpretation strategies. 

Understanding Electron Ionization for GC-MS

In this webcast, the fundamentals of electron ionization (EI) for GC-MS is presented. We will consider topics such as the anatomy of a typical EI source, the mechanisms of ionization, fragmentation and rearrangement reactions, and an introduction to EI mass spectral interpretation.

GC-MS Ionization Quick Guide

This short video will discuss the science and instrumentation which underpins GC-MS ionization.

GC-MS Column Selection

This short video will discuss the chemical and physical properties which must be considered when selecting a GC-MS column.

Practical GC-MS Video Bootcamp

The definitive guide to setting up a GC-MS instrument. Working on a real GC-MS instrument we provide you with the fundamental knowledge on the science, working principles, and correct setup of this powerful piece of equipment. An in-depth tour of how to dismantle and clean the ion source will give you confidence to perform preventative maintenance on your instrument.

GC-MS Acquisition Modes

GC-MS data acquisition is carried out using full scan or selected ion monitoring (SIM) mode. Scan mode is used to cover a wide range of m/z ratios, whereas, SIM is used to gather data for specific masses of interest. This module will explain the differences between the data generated, provide you with details on the parameters which can be set to acquire the data, and the impact of the acquisition mode and parameters on the sensitivity of that data.

GC-MS Library Searching

This module will detail the process of obtaining and extracting spectra for library matching, what is involved in the matching process, and interpreting match results. As well as providing learning on troubleshooting poor library matching.

Using Hydrogen as a Carrier Gas in GC-MS

For GC, switching an existing method from helium to hydrogen can often be relatively straightforward. For GC-MS though, there can be major challenges in making the switch. This module explores the common challenges and strategies that can be employed to resolve these.