CHROMacademy

Available to following accounts

Academic

Premier

LC-MS Method Parameters - Critical Evaluation

In this session, our speakers will consider a range of critical LC-MS method parameters and their impact on analytical sensitivity and specificity. The importance and impact of specific eluent chemistry, interface parameters, analyzer settings and types are all critically reviewed and evaluated in this highly relevant presentation.

Topics include:

Impact of mobile phase additives such as TFA, TEA, and ion pair reagents can have on analyte ionization
Effects of changing eluent modifier, buffer, and ionic strength in API LC-MS
How flow rates effect ionization and whether there is still a need to split column effluent flow
Importance and criticality of common source parameters such as nebulizing and drying gas flows, capillary and declustering potentials, sprayer position
Impact setting correct optimum scan cycle times and ion dwell times
When high resolution and/or high accuracy mass analyzers are required
How new LC-MS enabling column technologies permit enhanced ionization

LC-MS Method Parameters - Critical Evaluation

Profile