Orbitrap Mass Analyzers

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Orbitrap Mass Analyzers

Ion trapping techniques are important tools in mass spectrometry. However, traditional ion trap mass analyzers have disadvantages in either performance or high complexity and cost. The orbitrap, a new type of mass analyzer, has drawn attention due to its analytical performance in terms of resolution, mass accuracy, space charge capacity and linear dynamic range, and relatively small size and cost. This module will explore the theory and working principles of orbitrap mass analyzers.

Topics include:

Analyzer anatomy
Equations of motion
Continuous ion sources
Introduction to linear trapping devices
Linear quadrupole ion traps
Curved multipoles
Curved linear traps
Image current detection
Ion injection
Fourier transform (FT) mode
Fourier transform
Mass selective instability (MSI) mode
Multiply charged ions
Tune and calibration
High molecular weight application
Low molecular weight application
Comparison with other analyzers

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