Electrospray Ionization Instrumentation

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Electrospray Ionization Instrumentation

Electrospray is the dispersion of a liquid into electrically charged droplets, combining the two processes of droplet formation and droplet charging. This module discusses the major components of an electrospray interface and investigates methods for optimizing signal.

Topics include:

Electrospray source design
Electrospray capillary design
Source heating (drying gas)
T-piece designs
Optimizing sprayer/sampling plate configuration
Orthogonal spray source designs
Cluster ion sampling
Curtain gas systems to prevent cluster ions
Dielectric capillaries to prevent cluster ions
Source cleaning
Ion optics ring electrodes
Ion optics ion bridges
Collision induced dissociation
Effect of nozzle skimmer voltages
Collision induced dissociation probes

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