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Derivatization of analyte molecules in HPLC is primarily used to improve and/or allow detection; in particular for molecules which posses no (or weak) chromophores, fluorophores, or electrophores. Derivatization will inherently add time, complexity, and cost to the analytical workflow, however, this quick guide will help to determine if derivatization is suitable for your application by considering reasons for implementing derivatization and how this can be done.

HPLC Derivatization