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Fast HPLC is where we obtain the same (or better) separation, but with a shorter runtime. This is obtained simply by exploiting certain parameters (the column particle size, internal diameter, length and particle morphology) to increase the efficiency of the separation. If the column and conditions are more efficient we can do the same job in less time. This Quick Guide looks at the practical implementation of fast HPLC on standard HPLC equipment.

You Need a Fancy System to Run Fast HPLC – Or Do You?