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CHROMtalks - Optimizing Sample Introduction in GC through Focusing Techniques and Appropriate Inlet Selection

Gas chromatography (GC) is an analytical technique used to separate and analyze compounds in a sample based on their differences in volatility, with an additional influence of polarity. However, the influence of these parameters extends beyond separation; they affect the behavior of analytes throughout the whole chromatographic process, from injection to detection. Hence, the proper understanding of both boiling points and polarity is key as they define specific constraints related to the used equipment and chromatographic conditions. This short course aims to elucidate the process of selecting an appropriate column and GC inlet, beginning from a consideration of these two parameters.