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Method Development Optimization from Characterization to Purification of Oligonucleotides

Therapeutic oligonucleotides (oligos) have emerged as an area of particular interest and promise in biopharmaceutical research because of their potential to treat a wide range of diseases. These oligos can range in size, sequence complexity, and overall modifications. As a result, the analysis and purification of oligonucleotides by liquid chromatography is complex.  

In this webinar, we will discuss some of the unique chromatographic challenges that oligonucleotides present and offer method development guidelines and optimizations for analytical characterization through scale up to preparative purification.  

 

Topics include:

  • Understanding the analytical challenges that make chromatographic analysis of oligos so demanding 
  • Method development guidelines for analytical characterization of target oligonucleotide products 
  • Optimization of IP-RP analytical methods to improve resolution of your target product from closely related impurities
  • Tools to simplify method translation from analytical to prep scale purification 
  • A simplified approach to oligonucleotide analysis and purification

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