Measuring pH

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Measuring pH

pH is one of the most commonly determined parameters of aqueous (and non-aqueous) solutions because many chemical processes are dependent on pH. Altering pH can often significantly alter the rate of chemical reactions. The solubility and bioavailability of many pharmaceutically active compounds is also determined by solution pH. Furthermore, in chromatography, the retention and selectivity of ionizable analytes can be manipulated by changing the eluent pH. This module will discuss the equipment used to measure pH and how to use it.

Topics include:

Introduction and theory
pH paper and pH meters
pH meter electrodes
Buffer solution and pH electrode characteristics
Correct use of electrodes, electrode care, and maintenance
Calibrating a pH meter and making a measurement
Buffer preparation using the Henderson-Hasselbalch equation
Buffer preparation from stock solutions
Calculating the masses of buffer components
Calculating the pH of a strong acid solution
Calculating the pH of a strong base solution
Calculating the pH of a weak acid solution
Calculating the pH of a weak base solution
pH of common acids and bases

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