mAbs - Introduction to Monoclonal Antibodies

The term monoclonal antibody (mAb) is used to define a population of antibodies that are specific to a single antigen, which is what is required if mAbs are to be used as a biopharmaceutical therapy to target a specific disease or type of cancerous cell. This module provides an introduction to monoclonal antibodies.

Topics include:

• Introduciton to monoclonal antibodies
• Monoclonal antibodies
• mAb post-translational modifications (PTMs)
• Disulfide bond scrambling, isoforms, and aggregate formation
• Glycoform variation in N-linked glycans
• Deamidation
• N-terminal pyroglutamic residues
• C-terminal lysine truncation (clipping)
• Methionine oxidation