Method Development

Method Development Optimization from Characterization to Purification of Oligonucleotides

In this webcast, we will discuss some of the unique chromatographic challenges that oligonucleotides present and offer method development guidelines and optimizations for analytical characterization through scale up to preparative purification.  

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N-Glycan Separations: How HILIC Columns Affect Data Quality

This webcast will detail the selection of an appropriate HILIC column for n-glycan separations to ensure that glycans in complex mixtures are well-separated with minimal coelutions.

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Oligonucleotide Symposium: Solutions to Analytical Challenges, CMC Factors, and Compliance Considerations in Biopharmaceutical Manufacturing

This half-day symposium will take you on a journey through the world of oligonucleotides. Beginning at preparation and manufacture, then on to analytical method development and optimization, before ending with regulatory and compliance considerations.

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From Struggles to Solutions: Strategies for Overcoming Oligonucleotide Challenges

In this webcast, suggestions will be provided on column chemistry, mobile phase, column loading, and, most importantly, how to scale-up a method from analytical to prep. 

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Upgrading Your Aggregate Analysis of Viral Vectors with Novel Wide Pore SEC Columns

Learn more about the reproducible, high-resolution separations possible with wide pore SEC columns – and the time and cost savings that follow.

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CHROMtalks - The Use of Machine Learning to Automate Method Development for LC Separations of Biopharmaceuticals

In this webcast, the recent developments in automated method development for biopharmaceutical separations will be presented in the form of a roadmap. The role of data-analysis strategies and machine learning to advance automation will be addressed.

Column Selection for Improved Analytical Analysis and Preparative Purification of Oligonucleotides

This webcast will discuss how to achieve superior resolution and separation of oligo therapeutics from the many structurally similar impurities found in a crude sample. Understand how to scale up your optimized analytical method to semi-prep and preparative purification with the same column chemistry.  

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Advanced Column Selection and Method Optimization for Biomolecular Purification and Characterization

This webcast will discuss some of the most pressing challenges in biomolecular separations – including column selection for SEC/GPC based separations, oligonucleotide impurity characterizations as well as purification methods.

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Developing SEC Methods for Biologics Analysis

This quick guide focusses on the parameters which should be optimized in SEC analysis of biomolecules.

Selecting Columns and Initial Conditions for IEX and SEC Biomolecule Analysis

This quick guide discusses column selection and initial experimental conditions for developing IEX and SEC analyses of biomolecules.

Demystifying Reversed Phase Column Selection for Biomolecule Analysis

This quick walks you through selecting a reversed phase HPLC column for analyzing biomolecules.

Purification and Analysis of Synthetic Peptides: The Challenges of Method Development

In this webcast, we will present effective strategies to improve peptide purification via reversed-phase chromatography in order to optimize your purification methods and maximize the yield of separation.

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Method Development for Ion Exchange Using Dynamic Buffer Generation

This webcast will focus on understanding the complexity of biotherapeutic protein charge variant analysis and how optimization of weak cation exchange chromatography is a necessity.

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Choosing the Right Column for Intact Protein Characterization

This webcast will investigate some of the parameters you need to take into consideration when choosing the most appropriate chromatography column to get the best out of your instrumentation and provide the optimum resolution for your protein characterization.

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Choosing the Correct Column and Mobile Phase for LC-MS Peptide Mapping

This webcast will focus on essential parameters for successful peptide mapping by LC-MS.

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Choosing the Correct Column and Mobile Phase for LC-MS Characterization of Biologics

This webcast will focus on the parameters which are essential for the development of a successful RPLC-MS method for the characterization of a monoclonal antibody.

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Making the Right Choices in SEC Method Development

This webcast will focus on the parameters which are essential for the development of robust size exclusion methods.

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